marc anderson

Marc Anderson

	Name:	Marc, Anderson
	Education:	B.S. (1995) University of Colorado at Boulder, Computer Science Ph.D. (2001) University of California at Santa Cruz, Organic Chemistry
	At SFSU since:	1995
	Status:	Assistant Professor
	Office Location:	TH636
	Phone:	(415) 338-6495
	Email:
	Website:	http://plasmodium.sfsu.edu/~marc/research
	Office Hours:	M, 2-3pm, W, 3-4pm, F, 1:30-2:30pm
Organic Chemistry Our group uses organic synthesis and computational chemistry as tools to design inhibitors of therapeutically relevant drug targets in human illness. We are particularly interested in using structure-guided drug discovery techniques such as computational docking to aid in the discovery of potent and selective enzyme inhibitors. We are also interested in ligand-based drug discovery, notably using computational shape comparison software with known inhibitor scaffolds as a tool to identify novel classes of synthetically accessible inhibitors. Where possible, we plan to use parallel synthesis and purification (SPE, SPOS, etc.) techniques to improve the throughput of organic synthesis. We are currently developing inhibitors against several promising drug targets: IGF-1R (breast cancer), glutamate carboxypeptidase II (neuropathy and chronic pain), and PfHsp90 (malaria).
Publications:
Anderson, M. O.; Shellat, A. S.; Guy, R. K. (2005), "A novel solid-phase approach to the phallotoxins: total synthesis of [Ala7]-phalloidin." Journal of Organic Chemistry, 70(12), 4578-4584. Anderson, M. O.; Sherrill, J.; Liou, A. P.; Weisman, J. L.; DeRisi, J. L.; Guy, R. K. (2006). “Parallel synthesis of 9-aminoacridines and evaluation against chloroquine-resistant Plasmodium falciparum.” Bioorganic and Medicinal Chemistry, 14(2), 334-343. Anderson, M. O.; Yu, H.; Penaranda, C.; Maddux, B. A.; Goldfine, I. D.; Youngren, J. F.; Guy, R. K. (2006) “Parallel synthesis of diarylureas and evaluation against insulin-like growth factor receptor (IGF-1R).” Journal of Combinatorial Chemistry, 8(5), 784-790. May, B. C. H.; Witkop, J.; Sherrill, J.; Anderson, M.O.; Madrid, P. B.; Zorn, J. A.; Prusiner, S. B.; Cohen, F. E.; Guy, R. K. (2006) “Structure-activity relationship study of 9-aminoacridine compounds in scrapie-infected neuroblastoma cells.” Bioorganic and Medicinal Chemistry Letters, 16(18), 4913-3916. Blecha, J. E.; Anderson, M. O.; Chow, J. M.; Guevarra, C. C.; Pender, C.; Penaranda, C.; Zavodovskaya, M.; Youngren, J. F.; Berkman, C. E. (2007) "Inhibition of IGF-1R and Lipoxygenase by Nordihydroguaiaretic Acid (NDGA) Analogs" Bioorg Med. Chem. Lett. 17(14), 4026-4029. Anderson, M. O.; Santiago, N.; Moser, J.; Rowley, J. A.; Davis, E.; Berkman, C. B. (2007) “Substrate specificity of prostate-specific membrane antigen.” /Bioorganic and Medicinal Chemistry, Full paper, Accepted. Wu, L. Y.; Anderson, M. O.; Toriyabe, Y.; Maung, J.; Campbell, T. Y.; Tajon, C.; Kazak, M.; Moser, J.; Berkman, C. E. (2007) Bioorg. Med. Chem. "The Molecular Pruning of a Phosphoramidate Peptidomimetic Inhibitor of Prostate-Specific Membrane Antigen", Accepted. Wu, L. Y.; Do, J.; Kazak, M.; Page, H.; Toriyabe, Y.; Anderson, M. O.; Berkman, C. E. (2007) Bioorg. Med. Chem. Lett. "Phosphoramidate Derivatives of Hydroxysteroids as Inhibitors of Prostate-Specific Membrane Antigen", Submitted.
Grants and Awards:
Award: NIH R01 [CA-112042-01 A1] Role on the project: Co-investigator Description: "This grant is currently exploring the use of a diarylurea scaffold for its inhibitory potential against IGF-1R, a human kinase strongly implicated in the propagation of breast cancer."